Tr1 cell–dependent active tolerance blunts the pathogenic effects of determinant spreading
نویسندگان
چکیده
منابع مشابه
Tr1 cell-dependent active tolerance blunts the pathogenic effects of determinant spreading.
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated autoimmune disease of the CNS. The current study shows that even in an acute episode of disease the autoimmune response spreads from one determinant on myelin basic protein (MBP) to the other linked determinant and that this spread plays a functional role in the pathogenesis of disease. The soluble form of each determinant cou...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2002
ISSN: 0021-9738
DOI: 10.1172/jci0215176